Welcome to the web page for the Laboratory of Evolutionary Genetics at the National Institute of Genetics, Mishima, Japan.
Our laboratory studies mechanisms of genome evolution with a focus on detecting molecular variation with subtle functional and fitness effects. Natural selection can have an important impact on the long-term evolution of such mutations but cannot be measured directly in the laboratory or in natural populations. We investigate global adaptation in the genome through computational analyses of DNA sequence data available from public databases, theoretical studies of population genetic predictions for molecular evolution, and laboratory work to sequence DNA from within and between closely related species.